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Description

Excess visceral adipose tissue promotes a chronic inflammatory state, with macrophage infiltration releasing cytokines (e.g., interleukin-6, tumor necrosis factor-alpha) that impair endothelial nitric oxide bioavailability and increase myocardial stiffness via reduced cyclic GMP and protein kinase G activity [27]

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Official prescribing information is available via the NIH National Library of Medicine DailyMed database: Dosing Summary Dosing details above reflect FDA-approved labeling and/or published clinical protocols

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